Abstract: Oro facial clefts (OFC) are the most frequent birth defects worldwide. Cleft lip with/or palate are the major human orofacial congenital malformations seen in live birth as well as in still birth.Cleft lip and palate represent a major public health problem due to the possible associated life-long morbidity, complex etiology and the extensive multidisciplinary commitment required for intervention. The term "orofacial cleft" (OFC) covers a wide range of disorders affecting the lips and oral cavity which manifest in the new born infant. OFC involves structures around the oral cavity which can extend on to the facial structures resulting in oral, facial and craniofacial deformity. The main categories are isolated cleft palate (CP) and cleft lip with or without cleft palate (CL/P). Additionally, OFCs may be left- or right-sided (unilateral), or both sided (bilateral). Both types may present as part of a syndrome or other associated abnormalities....
[1]. EmanAllam, L Jack Windsor and Cynthia Stone. Cleft Lip and Palate: Etiology, Epidemiology, Preventive and Intervention Strategies. 1Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, IN, USA 2Oral and Dental Research Division, National Research Centre, Cairo, Egypt 3Department of Health Policy and Management, School of Public Health at IUPUI, Indianapolis, IN, USA. Jul 31, 2014
[2]. Watkins SE, Meyer RE, Strauss RP, Aylsworth AS. "Classification, epidemiology, and genetics of orofacial clefts".Clinics in Plastic Surgery. April 2014, 41 (2): 149–63.
[3]. Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC (2009) Cleft lip and palate. See comment in PubMed Commons below Lancet 374: 1773-1785.
[4]. Sinno H, Tahiri Y, Thibaudeau S, Izadpanah A, Christodoulou G, et al. (2012) Cleft lip and palate: an objective measure outcome study. See comment in PubMed Commons below PlastReconstrSurg 130: 408-414.
[5]. Wong FW, King NM (1998)The oral health of children with clefts--a review. See comment in PubMed Commons below Cleft Palate Craniofac J 35: 248-254